Chalcoplatin

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August undefined, 2024

WebChalcoplatin significantly induced p53 activation as well as the subsequent apoptosis pathways. This unique mode of action renders chalcoplatin remarkably cytotoxic and … WebMay 1, 2015 · Abstract. A nanoplatform targeting DNA and p53 simultaneously is assembled. Layered double hydroxide nanoparticles are co-loaded with a Pt (IV) prodrug and a p53 activator. Once inside cells, cisplatin is released to attack genomic DNA and kill cancer cells; simultaneously, the p53 activator results in active p53, a key protein …

PRIME PubMed Monochalcoplatin: An Actively Transported, …

WebChalcoplatin, a dual-targeting and p53 activator-containing anticancer platinum(iv) prodrug with unique mode of action DOI: 10.1039/c4cc10409a Source and publish data: Chemical Communications p. 6301 - 6304 (2015) Update date:2024-08-17. Authors: Ma, Lili Ma, Rong Wang, Yiping ... california driving permit classes

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WebMay 15, 2024 · 3. Drug targeting and delivery systems. Selective drug delivery is an important approach with great potential for overcoming problems associated with the systemic toxicity of chemotherapy, in particular, platinum-based chemotherapy [23, 24].Targeted drug therapy has two advantages over conventional chemotherapy: … WebCompared with its dicarboxylated counterpart chalcoplatin, monochalcoplatin accumulates astonishingly effectively and rapidly in cancer cells, which is not ascribed to its lipophilicity. The prodrug is quickly reduced, causes DNA damage, and induces apoptosis, resulting in superior cytotoxicity with IC50 values in the nanomolar range in both ... WebChalcoplatin, a dual-targeting and p53 activator-containing anticancer platinum (iv) prodrug with unique mode of action L Ma, R Ma, Y Wang, X Zhu, J Zhang, HC Chan, X Chen, W Zhang, ... Chemical Communications 51 (29), 6301-6304 , 2015 california driving points system

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WebDownload scientific diagram Cellular accumulationo fcDDP, chalcoplatin,a nd monochalcoplatin. A) A2780 cells, 6htreatment;B )A2780cisR cells, 6htreatment;C … WebMay 28, 2024 · Recently, Pt IV prodrugs have attracted much attention as the next generation of platinum‐based antineoplastic drug candidates. Here we report the … california driving permit requirementsWebMay 28, 2024 · Recently, Pt IV prodrugs have attracted much attention as the next generation of platinum‐based antineoplastic drug candidates. Here we report the discovery and evaluation of monochalcoplatin, a monocarboxylated Pt IV prodrug that is among the most cytotoxic Pt IV prodrugs to date. Compared with its dicarboxylated counterpart … california driving requirements for teens

"WebHere we report the discovery and evaluation of monochalcoplatin, a monocarboxylated PtIV prodrug that is among the most cytotoxic PtIV prodrugs to date. Compared with its … " - Chalcoplatin

Chalcoplatin

WebDec 30, 2024 · Probably, the most prominent example of this perception is so far represented by monochalcoplatin (Figure 1) that was extremely more active than its symmetric homologue chalcoplatin, despite its higher lipophilicity and the ability to deliver two active chalcone molecules from the latter (chalcone is an inhibitor of the p53 mouse … WebAug 1, 2016 · Chalcoplatin, a dual-targeting and p53 activator-containing anticancer platinum(IV) prodrug with unique mode of action. Ma L, Ma R, Wang Y, Zhu X, Zhang J, Chan HC, Chen X, Zhang W, Chiu SK, Zhu G. Chem Commun (Camb), (29):6301-6304 2015 MED: 25644651

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WebJan 27, 2015 · Chalcoplatin significantly induced p53 activation as well as the subsequent apoptosis pathways. This unique mode of action renders chalcoplatin remarkably … WebUse SelfDecode to get personalized health recommendations based on your genes. Get started today with an existing DNA file or order a SelfDecode DNA kit!

WebChalcoplatin, a dual-targeting and p53 activator-containing anticancer platinum(IV) prodrug with unique mode of action WebJan 10, 2024 · Chalcoplatin significantly induced p53 activation as well as the subsequent apoptosis pathways. This unique mode of action renders chalcoplatin remarkable cytotoxicity and makes this compound among the first examples of a Pt(IV) prodrug that directly interacts with the downstream pathway after the formation of Pt-DNA ...

WebMay 28, 2024 · Recently, Pt IV prodrugs have attracted much attention as the next generation of platinum-based antineoplastic drug candidates. Here we report the discovery and evaluation of monochalcoplatin, a … WebMay 28, 2024 · chalcoplatin, but not cisplatin and chalcoplatin, was able to. induce apoptosis after 6h (F igure S25). [5] After treatment of. A2780 and A2780cisR cells with 10 m m monochalcoplatin for.

Webshowed that, compared to cisplatin, chalcoplatin exhibited a markedly higher cytotoxicity (10-fold) for wild-type p53 cells but not for p53 null cells. Although the cellular accu-mulation increased, the Pt-DNA binding rate was not im-proved. Moreover, chalcoplatin mainly induced cell cycle arrest in the S and G2/M phases, whereas cisplatin and

WebChalcoplatin significantly induced p53 activation as well as the subsequent apoptosis pathways. This unique mode of action renders chalcoplatin remarkably cytotoxic and makes this compound among the first examples of a Pt(IV) prodrug that directly interacts with the downstream pathway after the formation of Pt-DNA lesions. coachworks toy haulerWebSep 8, 2024 · Chalcoplatin, a dual-targeting and p53 activator-containing anticancer platinum(IV) prodrug with unique mode of action Chem. Commun. , 51 ( 2015 ) , pp. 6301 - 6304 CrossRef View Record in Scopus Google Scholar california driving record request pdfhttp://bjp.sagepub.unboundmedicine.com/medline/citation/25644651/Chalcoplatin_a_dual_targeting_and_p53_activator_containing_anticancer_platinum_IV__prodrug_with_unique_mode_of_action_ california driving records online freeWebThe complex, called “chalcoplatin” by the authors, displayed significantly increased cytotoxicity in p53 wild-type but not in p53 null cells. Moreover, chalcoplatin effectively … california driving test 2021WebDespite the enormous importance of cisplatin as a chemotherapeutic agent, its application is impacted by dose-limiting side effects and lack of selectivity for cancer cells. Researchers can overcome these issues by taking advantage of the pro-drug nature of the platinum(IV) oxidation state, and by modifying the coordination sphere of the metal centre with … california driving rules headphonesWebChalcoplatin, a dual-targeting and p53 activator-containing anticancer platinum( iv ) prodrug with unique mode of action. Chemical Communications 2015, 51 (29) , 6301-6304. DOI: 10.1039/C4CC10409A. Katarzyna A. Mocniak, Ilona Kubajewska, Dominic E. M. Spillane, Gareth R. Williams, Russell E. Morris. ... coachworks thetfordWebMay 28, 2024 · Recently, Pt IV prodrugs have attracted much attention as the next generation of platinum-based antineoplastic drug candidates. Here we report the … california driving rules pdf