Photomutagenicity testing
WebThe Neutral Red uptake is measured by spectrometry and, if the test substance induces a cytotoxic effect. If the test substance induce a cytotoxic effect on the cells, the IC50 (i.e. the concentration producing 50 % reduction of viability) is calculated from the concentration-response. If achievable, the eight concentrations of each compound ... WebThe polycyclic aromatic hydrocarbon azulene and its naturally occurring derivative guaiazulene (1,4-dimethyl-7-isopropylazulene) are known to absorb light in the UV-vis …
Photomutagenicity testing
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WebApr 23, 2024 · Thus, the present work aims to evaluate the photomutagenicity of neuroleptic drug chlorpromazine (CPZ), and its N-demethylated metabolites using COMET assay and … WebAug 16, 2011 · In the Ames test, the mutagenicity of azulene was assessed in the presence and absence of UV light by use of the Salmonella strains TA102, TA104, TA2638 and E. …
Web@article{osti_5517617, title = {Chemical basis for photomutagenicity in synthetic fuels}, author = {Selby, C P and Calkins, J and Enoch, H G and Wright, C W and Wilson, B W}, abstractNote = {Photomutagens (chemicals that enhance the mutagenicity of near UV-visible radiation) have been detected in a variety of experimental coal- and oil shale … WebJul 1, 2016 · Pho-tomutagenesis test development: I. 8-Methoxypsoralen, chlorpromazine and sunscreen compounds in bacterial and yeast assays. Mutat. Res. 292:241–250 ... J. C. Dean, C. N. Martin, and D. J. Kirkland. 1992. Development of assays for the detection of photomutagenicity of chemicals during exposure to UV light. II. Results of testing three ...
WebJun 25, 2016 · The Relevance of Photomutagenicity Testing as a Predictor of Photocarcinogenicity. Lutz Müller and Peter Kasper View all authors and affiliations. Volume 17, Issue 5. ... Photocar cinogenicity testing in hairless mice of furocoumarins and several … WebThe Relevance of Photomutagenicity Testing as a Predictor of Photocarcinogenicity Show all authors. Lutz Müller. Lutz Müller. Federal Institute for Drugs and Medical Devices, Berlin, Germany ... Photocar cinogenicity testing in hairless mice of furocoumarins and several fluoroquinolones demonstrated a higher incidence and a shorter latent ...
WebThe first set of released assays, covering 14 KRAS, 29 EGFR, and the BRAF V600E mutations, underwent additional testing, including determination of (a) the difference in inherent …
WebThe relevance of photomutagenicity testing as a predictor of photocarcinogenicity. MUELLER L, KASPER P. Federal Inst. Drugs Med. Devices, Sect. Mutagenicity Carcinogenicity, Seestr. 10, 13353 Berlin, Germany. Today's lifestyle is associated with frequent and intense exposure to ultraviolet radiation (UVR). ... phone icon triangle with up and down arrowsWebstudies, phototoxicity and photomutagenicity testing. General issues regarding the assessment of metabolites and impurities, the assessment of the potential for endocrine … phone icsWebJan 1, 2004 · However, there are still no regulatory requirements for photomutagenicity, except a guideline issued by the Scientific Committee of Cosmetology (SSC) on the testing of sunscreens for their photochemical genotoxicity (Gocke et al., 2000; Loprieno, 1991), on which this work was based. phone id hex formatWebApr 1, 2013 · In this context, the authors have been involved over more than 20 years in the development and refinement of assays to test for photomutagenicity as an unwanted side … how do you own a townWebJan 1, 1990 · In contrast to the phototoxic and photomutagenic properties of many furocoumarins (psoralens), which are well documented in several test organisms and systems (reviewed by Song and Tapley, 1979), only few reports are known which deal with the photogenotoxicity or photomutagenicity of furoquinolines (Ashwood-Smith et al., … how do you own a chick fil aWebIn this context, the authors have been involved over more than 20 years in the development and refinement of assays to test for photomutagenicity as an unwanted side effect of UV … how do you own a houseWebOECD 487: In Vitro Mammalian Cell Micronucleus Test; OECD 490: Mouse Lymphoma Test; GMP & GLP Cytotoxicity Assays. ISO 10993-5: Tests for in vitro Cytotoxicity; LDH … how do you own a lighthouse